American scientists are mixed in pancreatic to 24 cancer after the specimen of patient of 22 brains tumor undertook gene is analysed, successful scale went out to include 20, the complete gene a collection of illustrative plates of 000 many gene, included individual gene mutation not only among them, still included to maintain the join access between each gene of tumor happening and development.
A collection of illustrative plates of this one genetics is writinged brush by the United States the scientist of center of cancer of Kimmel of Jin Si university finishs · Huo Pu about, two research are published in the Science Express September 5, 2008 as a result. Last year, the gene a collection of illustrative plates about breast cancer and knot rectum cancer also is finished by this research group.
Encode gene is choppy
The surviving rate of pancreatic cancer and cerebral tumor is very low. Investigator points out, this year, the United States will have 38, patient of cancer of pancreas of 000 new hair, among them 95% will die at this disease. The surviving rate of cerebral tumor is similar also, there is 20 every year about in the United States, case of illness of 000 new hair.
Consider to discover, in most case of illness, to tumour of avery kind of, 12 signal controlled way and the encode gene that conduct a process to produce gene mutation. For instance pancreatic cancer, about 67% ～ these 12 ways produced the patient of 100% to mutate. This included to participate in DNA to injure the 3 keys way that maturity of control, cell and tumour attack among them.
Investigator people the gene that used a few kinds to differ in this research analyses a method. They are called with a kind " high density small array " the enlarge that the technology discovered gene is added and be short of break; The method measuring order that uses new generation undertook an analysis to the expression of gene. In addition, investigator people still established new operation method, the data that has departure analyses conformity to undertake an analysis together; And still used a kind of technology, will harmful, the gene that stimulative tumour grows is choppy, with hurtless, right tumor grows to distinguish without the mutation of the influence come.
Investigator people still discover a few single gene are choppy, 83 when include pancreatic cancer are mixed polymorphous sex is colloid mother cell tumour (GBM, the tumor of a kind of brain with deadly the strongest sex) 42 mutation. In addition, the 70 many gene that still discovered albumen of encode cell surface have very remarkable excessive expression, can regard two kinds of tumour as to diagnose the target that checks with the sieve to nod these gene in the future.
Influence cure is decision-making
Investigator people discover at the same time, one kind is called IDH1 (dehydrogenation of different citric acid is enzymatic 1) gene, often appear in a kind of GBM choppy. In addition, apparent also in young GBM patient more common, and the patient survival rate that has mutation of this kind of gene is higher also. Study in place almost GBM of all afterwards hair sex (make progress from tumour of original low become divided and come) in, put the mutation that has this kind of gene, so, can pass later detect the mutation of this one gene, the tumour that will judge what low become divided may develop the GBM that becomes deadly sex.